This carefully revised Second Edition has been designed to address the challenges instructors face in teaching students with varied backgrounds and learning styles. Features such as Chemistry Review boxes provide additional resources for students who need them, while Toolboxes and Discovery boxes allow instructors the option to delve into more detail about physiology topics. In addition, several new clinical topics have been added to this edition. To help readers visualize physiology processes, every new copy of the book now includes the InterActive PhysiologyA (R) 8-System Suite CD-ROM, as well as access to an expanded Physiology Place website and PhysioExaA A 5.0 online laboratory simulations.